Dengue is one of the most common mosquito-borne viral illnesses worldwide. Dengue causes a wide spectrum of disease ranging from subclinical disease to severe flu-like symptoms in those infected. Today, severe dengue affects most Asian and Latin American countries and has become a leading cause of hospitalization and death among children and adults in these regions. Similar symptoms and laboratory findings between dengue and coronavirus disease (COVID-19) can pose a diagnostic challenge in dengue-endemic countries. Speakers will discuss the use of diagnostics with focus on implementation in endemic regions and present innovations and controversies in the clinical management of severe Dengue, including the use of novel therapeutics. Speakers will also highlight the challenges of unusual presentations that are now seen in higher frequency including Dengue induced organ specific damage unrelated to shock such as liver disease or encephalitis and presentations in the elderly.